TY - JOUR
T1 - Netamines O-S, Five New Tricyclic Guanidine Alkaloids from the Madagascar Sponge Biemna laboutei, and Their Antimalarial Activities
AU - Gros, Emmanuelle
AU - Martin, Marie Thérèse
AU - Sorres, Jonathan
AU - Moriou, Céline
AU - Vacelet, Jean
AU - Frederich, Michel
AU - Aknin, Maurice
AU - Kashman, Yoel
AU - Gauvin-Bialecki, Anne
AU - Al-Mourabit, Ali
N1 - Publisher Copyright:
© 2015 Verlag Helvetica Chimica Acta AG, Zürich.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - In our continuing program to isolate new compounds from the Madagascar sponge Biemna laboutei, five new tricyclic guanidine alkaloids, netamines O - S (1-5, resp.), have been identified together with the known compounds netamine E (6) and mirabilin J (7). The structures of all new netamines were assigned on the basis of spectroscopic analyses. Their relative configurations were established by analysis of ROESY data and comparison with literature data. Netamines O, P, and Q, which were isolated in sufficient quantities, were tested for their cytotoxic activities against KB cells and their activities against the malaria parasite Plasmodium falciparum. Netamines O and Q were found to be moderately cytotoxic. Netamines O, P, and Q exhibited antiplasmodial activities with IC50 values of 16.99±4.12, 32.62±3.44, and 8.37±1.35 μM, respectively.
AB - In our continuing program to isolate new compounds from the Madagascar sponge Biemna laboutei, five new tricyclic guanidine alkaloids, netamines O - S (1-5, resp.), have been identified together with the known compounds netamine E (6) and mirabilin J (7). The structures of all new netamines were assigned on the basis of spectroscopic analyses. Their relative configurations were established by analysis of ROESY data and comparison with literature data. Netamines O, P, and Q, which were isolated in sufficient quantities, were tested for their cytotoxic activities against KB cells and their activities against the malaria parasite Plasmodium falciparum. Netamines O and Q were found to be moderately cytotoxic. Netamines O, P, and Q exhibited antiplasmodial activities with IC50 values of 16.99±4.12, 32.62±3.44, and 8.37±1.35 μM, respectively.
KW - Antiplasmodial activity
KW - Biemna laboutei
KW - Cytotoxic activity
KW - Guanidine alkaloids
KW - Netamines O - S
UR - http://www.scopus.com/inward/record.url?scp=84947296720&partnerID=8YFLogxK
U2 - 10.1002/cbdv.201400350
DO - 10.1002/cbdv.201400350
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AN - SCOPUS:84947296720
SN - 1612-1872
VL - 12
SP - 1725
EP - 1733
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 11
ER -
