TY - JOUR
T1 - Netamines H-N, tricyclic alkaloids from the marine sponge biemna laboutei and their antimalarial activity
AU - Gros, Emmanuelle
AU - Al-Mourabit, Ali
AU - Martin, Marie Thérèse
AU - Sorres, Jonathan
AU - Vacelet, Jean
AU - Frederich, Michel
AU - Aknin, Maurice
AU - Kashman, Yoel
AU - Gauvin-Bialecki, Anne
PY - 2014/4/25
Y1 - 2014/4/25
N2 - Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 μM.
AB - Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 μM.
UR - https://www.scopus.com/pages/publications/84899519583
U2 - 10.1021/np4009283
DO - 10.1021/np4009283
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AN - SCOPUS:84899519583
SN - 0163-3864
VL - 77
SP - 818
EP - 823
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 4
ER -
