Netamines H-N, tricyclic alkaloids from the marine sponge biemna laboutei and their antimalarial activity

Emmanuelle Gros, Ali Al-Mourabit, Marie Thérèse Martin, Jonathan Sorres, Jean Vacelet, Michel Frederich, Maurice Aknin, Yoel Kashman, Anne Gauvin-Bialecki

Research output: Contribution to journalArticlepeer-review

Abstract

Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 μM.

Original languageEnglish
Pages (from-to)818-823
Number of pages6
JournalJournal of Natural Products
Volume77
Issue number4
DOIs
StatePublished - 25 Apr 2014

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