Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei

Hagit Sorek; Amira Rudi; Sophie Gueta; Fernando Reyes; Maria Jesus Martin; Maurice Aknin; Emile Gaydou; Jean Vacelet; Yoel Kashman

doi:10.1016/j.tet.2006.06.063

Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei

Hagit Sorek, Amira Rudi, Sophie Gueta, Fernando Reyes, Maria Jesus Martin, Maurice Aknin, Emile Gaydou, Jean Vacelet, Yoel Kashman^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI₅₀ values in the micromolar range.

Original language	English
Pages (from-to)	8838-8843
Number of pages	6
Journal	Tetrahedron
Volume	62
Issue number	37
DOIs	https://doi.org/10.1016/j.tet.2006.06.063
State	Published - 11 Sep 2006

Keywords

Guanidine alkaloids
Heterocyclic
Marine sponges

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tet.2006.06.063

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title = "Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei",

abstract = "In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI50 values in the micromolar range.",

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T2 - seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei

AU - Sorek, Hagit

AU - Rudi, Amira

AU - Gueta, Sophie

AU - Reyes, Fernando

AU - Martin, Maria Jesus

AU - Aknin, Maurice

AU - Gaydou, Emile

AU - Vacelet, Jean

AU - Kashman, Yoel

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Y1 - 2006/9/11

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AB - In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI50 values in the micromolar range.

KW - Guanidine alkaloids

KW - Heterocyclic

KW - Marine sponges

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Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei

Abstract

Keywords

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