Abstract
In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI50 values in the micromolar range.
Original language | English |
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Pages (from-to) | 8838-8843 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 62 |
Issue number | 37 |
DOIs | |
State | Published - 11 Sep 2006 |
Keywords
- Guanidine alkaloids
- Heterocyclic
- Marine sponges