Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei

Hagit Sorek; Amira Rudi; Sophie Gueta; Fernando Reyes; Maria Jesus Martin; Maurice Aknin; Emile Gaydou; Jean Vacelet; Yoel Kashman

doi:10.1016/j.tet.2006.06.063

Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei

Hagit Sorek, Amira Rudi, Sophie Gueta, Fernando Reyes, Maria Jesus Martin, Maurice Aknin, Emile Gaydou, Jean Vacelet, Yoel Kashman^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI₅₀ values in the micromolar range.

Original language	English
Pages (from-to)	8838-8843
Number of pages	6
Journal	Tetrahedron
Volume	62
Issue number	37
DOIs	https://doi.org/10.1016/j.tet.2006.06.063
State	Published - 11 Sep 2006

Keywords

Guanidine alkaloids
Heterocyclic
Marine sponges

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tet.2006.06.063

Cite this

@article{ae9a620660864837a4ca5f1f63ed7680,

title = "Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei",

abstract = "In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI50 values in the micromolar range.",

keywords = "Guanidine alkaloids, Heterocyclic, Marine sponges",

author = "Hagit Sorek and Amira Rudi and Sophie Gueta and Fernando Reyes and Martin, {Maria Jesus} and Maurice Aknin and Emile Gaydou and Jean Vacelet and Yoel Kashman",

year = "2006",

month = sep,

day = "11",

doi = "10.1016/j.tet.2006.06.063",

language = "אנגלית",

volume = "62",

pages = "8838--8843",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd.",

number = "37",

}

TY - JOUR

T1 - Netamines A-G

T2 - seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei

AU - Sorek, Hagit

AU - Rudi, Amira

AU - Gueta, Sophie

AU - Reyes, Fernando

AU - Martin, Maria Jesus

AU - Aknin, Maurice

AU - Gaydou, Emile

AU - Vacelet, Jean

AU - Kashman, Yoel

PY - 2006/9/11

Y1 - 2006/9/11

N2 - In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI50 values in the micromolar range.

AB - In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI50 values in the micromolar range.

KW - Guanidine alkaloids

KW - Heterocyclic

KW - Marine sponges

UR - http://www.scopus.com/inward/record.url?scp=33746698996&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2006.06.063

DO - 10.1016/j.tet.2006.06.063

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:33746698996

SN - 0040-4020

VL - 62

SP - 8838

EP - 8843

JO - Tetrahedron

JF - Tetrahedron

IS - 37

ER -

Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this