Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei

Hagit Sorek, Amira Rudi, Sophie Gueta, Fernando Reyes, Maria Jesus Martin, Maurice Aknin, Emile Gaydou, Jean Vacelet, Yoel Kashman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In our continuing program to identify bioactive compounds from marine invertebrates, the MeOH/EtOAc (1:1) extract of three collections of the Madagascar sponge, Biemna laboutei, was found to be cytotoxic to a series of human tumor cells. From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. Compounds 3 and 4 were found to be cytotoxic against three tumor cells with GI50 values in the micromolar range.

Original languageEnglish
Pages (from-to)8838-8843
Number of pages6
JournalTetrahedron
Volume62
Issue number37
DOIs
StatePublished - 11 Sep 2006

Keywords

  • Guanidine alkaloids
  • Heterocyclic
  • Marine sponges

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