Neonatal outcome of late preterm uncomplicated monochorionic twins: What is the optimal time for delivery?

Alexandra Berezowsky, Ram Mazkereth, Eran Ashwal, Shali Mazaki-Tovi, Eyal Schiff, Boaz Weisz, Shlomo Lipitz, Yoav Yinon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To determine the neonatal outcome at late prematurity of uncomplicated monochorionic (MC) twin pregnancies.Methods: A retrospective cohort study of 166 patients with uncomplicated MC diamniotic twins delivered between 34 and37 weeks of gestation at a single tertiary center. The study population was classified into four groups according to the gestational age at delivery: (1) 34 weeks, (2) 35 weeks, (3) 36 weeks and (4) 37 weeks. Neonatal outcome measures were compared between the groups.Results: Neonatal morbidity was significantly higher at 34 weeks of gestation compared to the other three groups including respiratory distress syndrome, oxygen requirement, hypothermia and hyperbilirubinemia. Moreover, the rate of admission to the special care unit and need for phototherapy were significantly higher in newborns born at 36 weeks compared to 37 weeks of gestation (p = 0.02 and 0.03 respectively). Multiple regression analysis revealed that the risk for adverse neonatal outcome was significantly associated with gestational age at delivery. Of note, there were no fetal or neonatal deaths in our cohort.Conclusions: The risk of neonatal morbidity of uncomplicated MC twins delivered at 34-37 weeks of gestation significantly decreases with advanced gestation. Therefore, under close fetal surveillance, uncomplicated MC twin pregnancies should be delivered at 37 weeks of gestation.

Original languageEnglish
Pages (from-to)1252-1256
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number8
StatePublished - 17 Apr 2016


  • Late prematurity
  • monochorionic twins
  • neonatal outcome
  • timing of delivery


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