Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy

Michal Kovo*, Ariel Weissman, Dvir Gur, David Levran, Sigi Rotmensch, Marek Glezerman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. The present study aimed to evaluate the effect of metformin exposure during pregnancy on neonates of polycystic ovarian syndrome (PCOS) patients. Method. Neonatal outcomes of 33 women with PCOS treated with metformin during pregnancy were compared to neonatal outcomes of 66 normal healthy women in a retrospective case-control study. Results. The mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls. After controlling for pregnancy complications, this observation became only marginally statistically significant. Conclusion. Although metformin is an attractive option for induction of ovulation in PCOS patients, there is a need for more evidence related to its safety during pregnancy.

Original languageEnglish
Pages (from-to)415-419
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume19
Issue number7
DOIs
StatePublished - 1 Jul 2006
Externally publishedYes

Keywords

  • Birth weight percentile
  • Pregnancy complications

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