Neonatal alloimmune thrombocytopenia due to anti‐P1A1 (anti‐hpa‐1a): Importance of paternal and fetal platelet typing for assessment of fetal risk

S. Lipitz, G. Ryan, M. F. Murphy, S. C. Robson, M. C.H. Haeusler, P. Metcalfe, H. Kelsey, C. H. Rodeck

Research output: Contribution to journalArticlepeer-review

Abstract

Neonatal alloimmune thrombocytopenia (NAIT), which usually involves sensitization to P1A1 (HPA‐1a), may have devastating complications for the fetus. These may be prevented by antenatal treatment of severe cases with either maternally administered high‐dose gamma‐globulin and/or repeated intrauterine platelet transfusions. Determination of the paternal platelet phenotype is useful for counselling parents who have had one or more affected pregnancies. This report of an unaffected pregnancy in a woman with a history of previous pregnancies complicated by NAIT illustrates the role of paternal and fetal platelet phenotyping in managing existing pregnancies at risk of NAIT.

Original languageEnglish
Pages (from-to)955-958
Number of pages4
JournalPrenatal Diagnosis
Volume12
Issue number11
DOIs
StatePublished - Nov 1992
Externally publishedYes

Keywords

  • Fetal blood sampling
  • Fetal/neonatal alloimmune thrombocytopenia
  • Paternal platelet phenotype

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