Negombins A-I, new chlorinated polyfunctional diterpenoids from the marine sponge negombata species

Amira Rudi, Yehuda Benayahu, Yoel Kashman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Nine novel compounds designated negombins A-I (1-9) were isolated, together with latrunculin, from the Tanzanian sponge Negombata sp. The nine are sacculatane type diterpenes, previously only known from liverworts. The structures of the compounds were elucidated by Interpretation of MS and 1D and 2D NMR spectra. A possible biogenesis initiated by the naturally rare chloronium ion is suggested, possibly hinting to a guest microorganism as the source of the compounds. Compound 4 is toxic to brine shrimp larvae.

Original languageEnglish
Pages (from-to)2337-2340
Number of pages4
JournalOrganic Letters
Volume9
Issue number12
DOIs
StatePublished - 7 Jun 2007

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