Needle-Tipped Catheter Ablation of Papillary Muscle Results in Deeper and Larger Ablation Lesions

Udi Nussinovitch, Paul Wang, Meghedi Babakhanian, Sanjiv M. Narayan, Mohan Viswanathan, Nitish Badhwar, Lijun Zheng, William H. Sauer, Duy T. Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Ventricular tachycardia associated with papillary muscle (PM) is often refractory to standard radiofrequency ablation (RFA). The needle-tipped ablation catheter (NT-AC) has been used to treat deep intramyocardial substrates, but its use for PM has not been characterized. Using an ex vivo experimental platform, both 3 mm and 6 mm NT-AC created larger ablation lesion volumes and depths than open-irrigated ablation catheter did (OI-AC; e.g., 57.12 ± 9.70mm3 and 2.42 ± 0.22 mm, respectively; p < 0.01 for all comparisons). Longer NT-AC extension (6 mm) resulted in greater ablation lesion volumes and maximum depths (e.g., 333.14 ± 29.13mm3 and 6.46 ± 0.29 mm, respectively, compared to the shorter 3 mm NT-AC extension, 143.33 ± 12.77mm3, and 4.46 ± 0.14 mm; both p < 0.001). There were no steam pops. In conclusion, for PM ablation, the NT-AC was able to achieve ablation lesions that were larger and deeper than with conventional OI-AC. Ablation of PM may be another application for needle-tip ablation. Further studies are warranted to establish long-term safety and efficacy in human studies. Graphical abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)636-643
Number of pages8
JournalJournal of Cardiovascular Translational Research
Issue number3
StatePublished - Jun 2023
Externally publishedYes


  • Needle-tipped ablation catheter (NT-AC)
  • Open-irrigated ablation catheter (OI-AC)
  • Papillary muscle (PM)
  • Radiofrequency ablation (RFA)
  • Ventricular tachycardia (VT)


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