Needle embryofetoscopy and early prenatal diagnosis

E. Albert Reece*, Carol J. Homko, Arnon Wiznitzer, Israel Goldstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Needle embroyfetoscopy (NEF) permits direct visualization of the embryo/fetus with a specially designed 16-gauge double-barrel instrument sheath which is passed transabdominally into the amniotic cavity. We report the case of a woman with a MSAFP of 2.5 MOM who had declined amniocentesis. A targeted ultrasound examination of the spine revealed what appeared to be spina bifida in the lumbar sacral segments from L2 to S1. The mother elected to undergo NEF at 15 weeks gestation, which was successfully performed and revealed no evidence of a neural tube defect. NEF has a tremendous potential for both early prenatal diagnosis, and possibly fetal treatment.

Original languageEnglish
Pages (from-to)81-82
Number of pages2
JournalFetal Diagnosis and Therapy
Issue number2
StatePublished - 1995
Externally publishedYes


  • Needle embryofetoscopy
  • Prenatal diagnosis
  • Spina bifida


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