Necrotizing Hemorrhagic Gastritis following Acute Myeloid Leukemia Induction with Midostaurin: An Unexpected Complication

Shai Shimony; Hilla Reiss Mintz; Yulia Shvartser Beryozkin; Avivit Shoham; Pia Raanani; Ofir Wolach

doi:10.1159/000500975

Necrotizing Hemorrhagic Gastritis following Acute Myeloid Leukemia Induction with Midostaurin: An Unexpected Complication

Shai Shimony, Hilla Reiss Mintz, Yulia Shvartser Beryozkin, Avivit Shoham, Pia Raanani, Ofir Wolach

Hematology

Research output: Contribution to journal › Article › peer-review

Abstract

Midostaurin is a tyrosine multikinase inhibitor approved for the treatment of patients with newly diagnosed acute myeloid leukemia (AML) with mutated Fms-like tyrosine kinase-3. We describe a case report of a 49-year-old AML patient treated with an intensive chemotherapy regimen followed by midostaurin. After achieving complete remission with blood count recovery, he suffered from a serious, rare complication of necrotizing hemorrhagic gastritis with no evidence of infection or malignant infiltration, possibly associated with midostaurin therapy.

Original language	English
Pages (from-to)	65-68
Number of pages	4
Journal	Acta Haematologica
Volume	143
Issue number	1
DOIs	https://doi.org/10.1159/000500975
State	Published - 1 Jan 2020

Keywords

Acute myeloid leukemia
Hemorrhagic gastritis
Midostaurin

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10.1159/000500975

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abstract = "Midostaurin is a tyrosine multikinase inhibitor approved for the treatment of patients with newly diagnosed acute myeloid leukemia (AML) with mutated Fms-like tyrosine kinase-3. We describe a case report of a 49-year-old AML patient treated with an intensive chemotherapy regimen followed by midostaurin. After achieving complete remission with blood count recovery, he suffered from a serious, rare complication of necrotizing hemorrhagic gastritis with no evidence of infection or malignant infiltration, possibly associated with midostaurin therapy.",

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AU - Shoham, Avivit

AU - Raanani, Pia

AU - Wolach, Ofir

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AB - Midostaurin is a tyrosine multikinase inhibitor approved for the treatment of patients with newly diagnosed acute myeloid leukemia (AML) with mutated Fms-like tyrosine kinase-3. We describe a case report of a 49-year-old AML patient treated with an intensive chemotherapy regimen followed by midostaurin. After achieving complete remission with blood count recovery, he suffered from a serious, rare complication of necrotizing hemorrhagic gastritis with no evidence of infection or malignant infiltration, possibly associated with midostaurin therapy.

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Necrotizing Hemorrhagic Gastritis following Acute Myeloid Leukemia Induction with Midostaurin: An Unexpected Complication

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