Natural progression of helicobacter pylori-negative gastritis with lymphoid follicles in children: Prospective evaluation and outcome

Vered Richter*, Sonia Mendlovic, Tzipi Shalem, Adi Eindor-Abarbanel, Haim Shirin, Efrat Broide

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: The association of Helicobacter pylori-negative gastritis with lymphoid follicles (LFs) in children is still unclear. Therefore, we aimed to investigate the natural history and significance of H. pylori-negative gastritis with LFs in children. Methods: We identified children with histologically proven H. pylori-negative gastritis with LFs between June 2014 and January 2017. The children were invited for a follow-up examination. The clinical, endoscopic, and histological findings of the index esophagogastroduodenoscopy (EGD) were revised and compared to the follow-up findings. Results: A total of 754 children underwent EGD. Among the 48 children diagnosed with H. pylori-negative gastritis, 17 (35.41%) had gastric LFs. Eight agreed to participate in the study. The mean follow-up was 25.58 ± 4.52 (range, 20.53-35.73) months. Three children still had histologic findings of chronic gastritis with LFs. Four children had resolution of the gastritis but still had LFs, and 1 patient had resolution of both the gastritis and LFs. Conclusion: LFs were still present in children with H. pylori-negative gastritis after a mean follow-up of 2 years, and in some children, despite resolution of the gastritis. Therefore, this histological finding might be a non-pathological feature in children and does not need any contribution or follow-up.

Original languageEnglish
Pages (from-to)575-580
Number of pages6
JournalTurkish Journal of Gastroenterology
Volume32
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • Gastritis
  • H. pylori-negative
  • Lymphoid aggregates
  • Lymphoid follicles

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