Natural probiotics improve heritable sterility

Chee Kiang Ewe*, Oded Rechavi*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

Disrupting the small RNA pathway and chromatin-modifying enzymes in C. elegans often leads to a mortal germline (Mrt) phenotype, characterized by progressive sterility observed over multiple generations at elevated temperature. This phenotype arises from the inheritance of aberrant epigenetic memory across generations. In this issue of EMBO Reports, Frézal and colleagues reported that, while in standard laboratory environment C. elegans wild isolates exhibit the Mrt phenotype, sterility does not occur when the worms are exposed to naturally associated bacteria and microsporidia. Excitingly, diet-induced epigenetic memory may persist for multiple generations. This suggests intriguing diet–gene interactions in modulating nongenetic inheritance, potentially shaping the evolutionary trajectory of the animals.

Original languageEnglish
Article numbere58318
JournalEMBO Reports
Volume24
Issue number12
DOIs
StatePublished - 6 Dec 2023

Funding

FundersFunder number
Morris Kahn Foundation
European Molecular Biology Organization0140001000, 6‐2022
European Research Council335624

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