TY - JOUR
T1 - Natural probiotics improve heritable sterility
AU - Ewe, Chee Kiang
AU - Rechavi, Oded
N1 - Publisher Copyright:
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
PY - 2023/12/6
Y1 - 2023/12/6
N2 - Disrupting the small RNA pathway and chromatin-modifying enzymes in C. elegans often leads to a mortal germline (Mrt) phenotype, characterized by progressive sterility observed over multiple generations at elevated temperature. This phenotype arises from the inheritance of aberrant epigenetic memory across generations. In this issue of EMBO Reports, Frézal and colleagues reported that, while in standard laboratory environment C. elegans wild isolates exhibit the Mrt phenotype, sterility does not occur when the worms are exposed to naturally associated bacteria and microsporidia. Excitingly, diet-induced epigenetic memory may persist for multiple generations. This suggests intriguing diet–gene interactions in modulating nongenetic inheritance, potentially shaping the evolutionary trajectory of the animals.
AB - Disrupting the small RNA pathway and chromatin-modifying enzymes in C. elegans often leads to a mortal germline (Mrt) phenotype, characterized by progressive sterility observed over multiple generations at elevated temperature. This phenotype arises from the inheritance of aberrant epigenetic memory across generations. In this issue of EMBO Reports, Frézal and colleagues reported that, while in standard laboratory environment C. elegans wild isolates exhibit the Mrt phenotype, sterility does not occur when the worms are exposed to naturally associated bacteria and microsporidia. Excitingly, diet-induced epigenetic memory may persist for multiple generations. This suggests intriguing diet–gene interactions in modulating nongenetic inheritance, potentially shaping the evolutionary trajectory of the animals.
UR - http://www.scopus.com/inward/record.url?scp=85177465236&partnerID=8YFLogxK
U2 - 10.15252/embr.202358318
DO - 10.15252/embr.202358318
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.comment???
C2 - 37983676
AN - SCOPUS:85177465236
SN - 1469-221X
VL - 24
JO - EMBO Reports
JF - EMBO Reports
IS - 12
M1 - e58318
ER -