Natural history of fetal isolated ventriculomegaly: Comparison between pre- and post-natal imaging

Sharon Perlman*, Omer Bar-Yosef, Jeffrey Michael Jacobson, Yinon Gilboa, Estela Derazne, Reuven Achiron, Eldad Katorza

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: The aim of our study was to assess the agreement between pre- and post-natal measurements in prenatal isolated ventriculomegaly. Methods: Ninety-two women were referred for lateral ventricular abnormality and followed prospectively. Cases with at least one dilated lateral ventricle ≥10 mm and a normal work up (serological tests, detailed anatomical scan, fetal brain MR imaging, genetic counseling, and amniocentesis) were considered idiopathic ventriculomegaly and comprised the study group for post-natal follow up. Prenatal measurements were performed by ultrasound and MR imaging. Post-natal measurements were performed by cranial sonography at age of 1–3 months. Measurements were performed in the customary plane for each modality. Paired Student’s t test was used to assess the mean difference between pre- and postnatal measurements. Results: Forty three cases comprised the study group for post-natal measurements. A statistically significant decrease in ventricular width (p <.001) was observed between pre- and post-natal measurements. On clinical follow up for 24 months, all cases were normal except three who demonstrated very mild neurological deficits. Conclusions: Our study indicates statistically significant regression of prenatal isolated ventriculomegaly in the post-natal period.

Original languageEnglish
Pages (from-to)1762-1767
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number13
StatePublished - 3 Jul 2018


  • Isolated ventriculomegaly
  • MRI
  • post-natal
  • pre-natal
  • ultrasound


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