TY - JOUR
T1 - Nascent Geographic Atrophy as a Predictor of Type 3 Macular Neovascularization Development
AU - Sacconi, Riccardo
AU - Sarraf, David
AU - Sadda, Srini Vas R.
AU - Freund, K. Bailey
AU - Servillo, Andrea
AU - Fogel Levin, Meira Miri
AU - Costanzo, Eliana
AU - Corradetti, Giulia
AU - Cabral, Diogo
AU - Zur, Dinah
AU - Trivizki, Omer
AU - Parravano, Mariacristina
AU - Bandello, Francesco
AU - Loewenstein, Anat
AU - Querques, Giuseppe
N1 - Publisher Copyright:
© 2023 American Academy of Ophthalmology
PY - 2023/7
Y1 - 2023/7
N2 - Purpose: To investigate the association of nascent geographic atrophy (GA) preceding the development of exudative type 3 macular neovascularization (MNV) in patients with age-related macular degeneration (AMD). Design: Retrospective longitudinal study. Participants: Patients with AMD diagnosed with treatment-naive exudative type 3 MNV in 1 or both eyes were evaluated. Inclusion criteria included serial tracked structural OCT examinations for ≥ 2 years before the detection of exudative type 3 MNV. Methods: Clinical characteristics and retinal imaging, including structural OCT at baseline and at each follow-up examination, were analyzed. Eyes showing the presence of nascent GA during the follow-up were selected for analysis of prevalence, and clinical characteristics at the site of subsequent type 3 MNV development. Main Outcome Measures: Description of the prevalence and clinical characteristics of nascent GA at the site of subsequent type 3 MNV development. Results: Overall, 97 eyes affected by type 3 MNV meeting inclusion criteria were analyzed. Of 97 eyes (71 patients), 22 eyes of 21 patients (mean age 82 ± 9 years) showed nascent GA preceding exudative type 3 MNV. The observed prevalence of nascent GA preceding exudative type 3 MNV was 22.7% (95% confidence interval, 14.4%–31.0%). Exudative type 3 MNV developed a mean of 9 ± 6 months after detection of nascent GA. The presence of reticular pseudodrusen in the study eye did not significantly influence the timing of exudative type 3 MNV development after the observation of nascent GA (P > 0.1 in all analyses). Reduced best-corrected visual acuity was recorded at the exudative type 3 stage in comparison with the nascent GA stage (P = 0.003). Conclusions: As nascent GA may precede the development of exudative type 3 MNV, the detection of nascent GA in eyes with AMD may warrant closer surveillance to identify early exudative type 3 MNV warranting treatment. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.
AB - Purpose: To investigate the association of nascent geographic atrophy (GA) preceding the development of exudative type 3 macular neovascularization (MNV) in patients with age-related macular degeneration (AMD). Design: Retrospective longitudinal study. Participants: Patients with AMD diagnosed with treatment-naive exudative type 3 MNV in 1 or both eyes were evaluated. Inclusion criteria included serial tracked structural OCT examinations for ≥ 2 years before the detection of exudative type 3 MNV. Methods: Clinical characteristics and retinal imaging, including structural OCT at baseline and at each follow-up examination, were analyzed. Eyes showing the presence of nascent GA during the follow-up were selected for analysis of prevalence, and clinical characteristics at the site of subsequent type 3 MNV development. Main Outcome Measures: Description of the prevalence and clinical characteristics of nascent GA at the site of subsequent type 3 MNV development. Results: Overall, 97 eyes affected by type 3 MNV meeting inclusion criteria were analyzed. Of 97 eyes (71 patients), 22 eyes of 21 patients (mean age 82 ± 9 years) showed nascent GA preceding exudative type 3 MNV. The observed prevalence of nascent GA preceding exudative type 3 MNV was 22.7% (95% confidence interval, 14.4%–31.0%). Exudative type 3 MNV developed a mean of 9 ± 6 months after detection of nascent GA. The presence of reticular pseudodrusen in the study eye did not significantly influence the timing of exudative type 3 MNV development after the observation of nascent GA (P > 0.1 in all analyses). Reduced best-corrected visual acuity was recorded at the exudative type 3 stage in comparison with the nascent GA stage (P = 0.003). Conclusions: As nascent GA may precede the development of exudative type 3 MNV, the detection of nascent GA in eyes with AMD may warrant closer surveillance to identify early exudative type 3 MNV warranting treatment. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.
KW - Age-related macular degeneration
KW - Geographic atrophy
KW - Nascent GA
KW - Nascent type 3
KW - Type 3 neovascularization
UR - http://www.scopus.com/inward/record.url?scp=85150789531&partnerID=8YFLogxK
U2 - 10.1016/j.oret.2023.01.019
DO - 10.1016/j.oret.2023.01.019
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 36736896
AN - SCOPUS:85150789531
SN - 2468-6530
VL - 7
SP - 586
EP - 592
JO - Ophthalmology Retina
JF - Ophthalmology Retina
IS - 7
ER -