Nasal nitric oxide does not control basal nasal patency or acute congestion following allergen challenge in allergic rhinitis

Philip E. Silkoff, Philip Cole, Yehuda Roth, Jerry Chapnik, Patricia McClean, Noe Zamel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Nasal nitric oxide (NO), a powerful vasodilator, could control the filling of nasal capacitance vessels, thus determining nasal patency and mediating the acute congestion accompanying allergen challenge. We examined the effect of topical N-nitro-L-arginine-methyl-ester (L-NAME; 100 to 200 mg), an NO synthase inhibitor, on nasal NO and on nasal patency assessed by acoustic rhinometry in 7 subjects with nasal allergy, and in 4 subjects we examined the effects of nasal allergen challenge on nasal NO before and after a short course of nasal steroid. After L-NAME, nasal NO fell to 42.1% ± 15.7% of baseline (p < .0001) with no significant change in minimal cross- sectional area. After allergen challenge, acute congestion was associated with a significant fall in nasal NO, which returned to baseline by 4 hours, when the congestion resolved. Repeat challenge after 2 weeks of nasal corticosteroid yielded similar findings. A role for NO in modulating vascular tone was not supported by the present study.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalAnnals of Otology, Rhinology and Laryngology
Volume108
Issue number4 I
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Acoustic rhinometry
  • L-NAME
  • Nasal patency
  • Nitric oxide
  • Nose

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