Narcolepsy and H1N1 vaccine

María Teresa Arango, Shaye Kivity, Nancy Agmon-Levin, Gili Givaty, Joab Chapman, Yehuda Shoenfeld

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Narcolepsy is a sleep disorder described as excessive sleepiness with abnormal sleep pattern characterized by uncontrollable rapid eye movement (REM) attacks, in which the preceding non-REM stage is absent. These attacks can occur at any time of the day and can be accompanied by a loss of muscle tone. A plethora of data indicates that narcolepsy is caused by a lack of orexin, an important neurotransmitter involved in the regulation of the sleep cycle. Normal levels of orexin are needed for the correct function of different processes in the body, including feeding, cardiovascular regulation, emotions, and locomotion. The pathogenesis of narcolepsy has been debated for many years. It has been suggested that genetic, autoimmune, or infectious processes may be involved. An important aspect in the etiology of narcolepsy is some reports demonstrating a correlation between its onset and infections or H1N1 vaccination.

Original languageEnglish
Title of host publicationVaccines and Autoimmunity
Number of pages10
ISBN (Electronic)9781118663721
ISBN (Print)9781118663431
StatePublished - 1 Jan 2014


  • H1N1 vaccination
  • Narcolepsy
  • Orexin
  • Rapid eye movement (REM) attacks


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