Naphthoquinone–Dopamine Hybrids Inhibit α-Synuclein Aggregation, Disrupt Preformed Fibrils, and Attenuate Aggregate-Induced Toxicity

Keyphrases

• Parkinson's Disease 100%
• Alpha-synuclein (α-syn) 100%
• Induced Toxicity 100%
• Preformed Fibrils 100%
• Small Molecules 33%
• Neurodegenerative Diseases 33%
• Amyloid Fibrils 33%
• Blood-brain Barrier 33%
• Neuroblastoma Cells 33%
• Congo Red 33%
• Low Cytotoxicity 33%
• Amyloid Formation 33%
• Blood-brain Barrier Model 33%
• Hybrid Molecules 33%
• Disease-modifying Therapy 33%
• Neuroblastoma SH-SY5Y Cells 33%
• Intrinsically Disordered Proteins 33%
• Birefringence 33%
• Therapeutic Design 33%
• Leak Test 33%
• Synucleinopathy 33%
• CD-TEM 33%
• ThT Assay 33%

Biochemistry, Genetics and Molecular Biology

• Amyloid 100%
• Synuclein 100%
• Cytotoxicity 50%
• Small Molecule 50%
• Blood Brain Barrier 50%
• Intrinsically Disordered Protein 50%
• Congo Red 50%
• Birefringence 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Parkinson's Disease 100%
• Synuclein 100%
• Disease 66%
• Amyloid 66%
• Cytotoxicity 33%
• Neuroblastoma 33%
• Intrinsically Disordered Protein 33%
• Congo Red 33%
• Synucleinopathies 33%