Naphthalene induced fatal haemolysis in G6PD deficiency

Zinaida Fradin; Gideon Y. Stein; Meir Varon; Pazit Kanter; Aliza Zeidman

Naphthalene induced fatal haemolysis in G6PD deficiency

Zinaida Fradin, Gideon Y. Stein, Meir Varon, Pazit Kanter, Aliza Zeidman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Naphthalene is widely used as an industrial and household chemical with low toxicity. Most cases of accidental poisoning have been described in children. The haematologic, renal and neurologic systems are mainly affected in naphthalene poisoning. We report here an 83-year-old patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency and suicide attempt by naphthalene ingestion. The patient developed severe haemolytic anaemia as well as methemoglobinaemia and acute oliguric renal failure. In addition, high anion gap metabolic acidosis was found. Finally, the patient entered a comatose state and died on the eighth day despite aggressive treatment.

Original language	English
Pages (from-to)	286-288
Number of pages	3
Journal	HAEMA
Volume	8
Issue number	2
State	Published - Apr 2005

Keywords

Metabolic acidosis
Methemoglobinemia
Microangiopathic hemolytic anemia
Naphthalene

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Naphthalene is widely used as an industrial and household chemical with low toxicity. Most cases of accidental poisoning have been described in children. The haematologic, renal and neurologic systems are mainly affected in naphthalene poisoning. We report here an 83-year-old patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency and suicide attempt by naphthalene ingestion. The patient developed severe haemolytic anaemia as well as methemoglobinaemia and acute oliguric renal failure. In addition, high anion gap metabolic acidosis was found. Finally, the patient entered a comatose state and died on the eighth day despite aggressive treatment.",

keywords = "Metabolic acidosis, Methemoglobinemia, Microangiopathic hemolytic anemia, Naphthalene",

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AU - Stein, Gideon Y.

AU - Varon, Meir

AU - Kanter, Pazit

AU - Zeidman, Aliza

PY - 2005/4

Y1 - 2005/4

N2 - Naphthalene is widely used as an industrial and household chemical with low toxicity. Most cases of accidental poisoning have been described in children. The haematologic, renal and neurologic systems are mainly affected in naphthalene poisoning. We report here an 83-year-old patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency and suicide attempt by naphthalene ingestion. The patient developed severe haemolytic anaemia as well as methemoglobinaemia and acute oliguric renal failure. In addition, high anion gap metabolic acidosis was found. Finally, the patient entered a comatose state and died on the eighth day despite aggressive treatment.

AB - Naphthalene is widely used as an industrial and household chemical with low toxicity. Most cases of accidental poisoning have been described in children. The haematologic, renal and neurologic systems are mainly affected in naphthalene poisoning. We report here an 83-year-old patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency and suicide attempt by naphthalene ingestion. The patient developed severe haemolytic anaemia as well as methemoglobinaemia and acute oliguric renal failure. In addition, high anion gap metabolic acidosis was found. Finally, the patient entered a comatose state and died on the eighth day despite aggressive treatment.

KW - Metabolic acidosis

KW - Methemoglobinemia

KW - Microangiopathic hemolytic anemia

KW - Naphthalene

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EP - 288

JO - HAEMA

JF - HAEMA

IS - 2

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Naphthalene induced fatal haemolysis in G6PD deficiency

Abstract

Keywords

UN SDGs

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