NAP mechanisms of neuroprotection

Illana Gozes*, Ruth A. Steingart, Avron D. Spier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


An 8-amino-acid peptide, NAPVSIPQ (NAP), was identified as the smallest active element of activity-dependent neuroprotective protein that exhibits potent neuroprotective action. Potential signal transduction pathways include cGMP production and interference with inflammatory mechanisms, tumor necrosis factor-α, and MAC1-related changes. Because of its intrinsic structure, NAP might interact with extracellular proteins and also transverse membranes. NAP-associated protection against oxidative stress, glucose deprivation, and apoptotic mechanisms suggests interference with fundamental processes. This paper identifies p53, a key regulator of cellular apoptosis, as an intracellular target for NAP's activity.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalJournal of Molecular Neuroscience
Issue number1
StatePublished - Aug 2004


FundersFunder number
Allon Therapeutics Inc.
Institute for the Study of Aging
National Institute on Aging
National Institute of Child Health and Human Development
United States-Israel Binational Science Foundation
Israel Science Foundation


    • Neuroprotection
    • Peptides


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