TY - JOUR
T1 - NAP mechanisms of neuroprotection
AU - Gozes, Illana
AU - Steingart, Ruth A.
AU - Spier, Avron D.
N1 - Funding Information:
These studies were supported by the Institute for the Study of Aging, the US–Israel Binational Science Foundation, The Neufeld Award for an outstanding US–Israel Binational Science Foundation proposal in health sciences, the Israeli Science Foundation, the Lily and Avraham Gildor Chair for the Investigation of Growth Factors, the NIA, the National Institute of Child Health and Human Development (NICHD) and Allon Therapeutics Inc.
PY - 2004/8
Y1 - 2004/8
N2 - An 8-amino-acid peptide, NAPVSIPQ (NAP), was identified as the smallest active element of activity-dependent neuroprotective protein that exhibits potent neuroprotective action. Potential signal transduction pathways include cGMP production and interference with inflammatory mechanisms, tumor necrosis factor-α, and MAC1-related changes. Because of its intrinsic structure, NAP might interact with extracellular proteins and also transverse membranes. NAP-associated protection against oxidative stress, glucose deprivation, and apoptotic mechanisms suggests interference with fundamental processes. This paper identifies p53, a key regulator of cellular apoptosis, as an intracellular target for NAP's activity.
AB - An 8-amino-acid peptide, NAPVSIPQ (NAP), was identified as the smallest active element of activity-dependent neuroprotective protein that exhibits potent neuroprotective action. Potential signal transduction pathways include cGMP production and interference with inflammatory mechanisms, tumor necrosis factor-α, and MAC1-related changes. Because of its intrinsic structure, NAP might interact with extracellular proteins and also transverse membranes. NAP-associated protection against oxidative stress, glucose deprivation, and apoptotic mechanisms suggests interference with fundamental processes. This paper identifies p53, a key regulator of cellular apoptosis, as an intracellular target for NAP's activity.
KW - Neuroprotection
KW - Peptides
UR - http://www.scopus.com/inward/record.url?scp=16544395626&partnerID=8YFLogxK
U2 - 10.1385/jmn:24:1:067
DO - 10.1385/jmn:24:1:067
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AN - SCOPUS:16544395626
SN - 0895-8696
VL - 24
SP - 67
EP - 72
JO - Journal of Molecular Neuroscience
JF - Journal of Molecular Neuroscience
IS - 1
ER -
