@inbook{8dadb1346e1448e68aea74cfa358a4a5,
title = "NAP: A novel candidate for AD",
abstract = "Peptide-neuroprotective activity scanning of activity-dependent neuroprotective protein (ADNP), a protein essential for brain formation, identified NAP (NAPVSIPQ) as a potent neuroprotective peptide in cell culture. In vivo, NAP provided neuroprotection in an animal model of apolipoprotein E deficiency. Since the lipid carrier, apolipoprotein E has been implicated as a risk factor in AD, and since the knock-out mice exhibit short-term memory deficits that are ameliorated by chronic peptide treatment, this peptide holds promise for future treatment against short-term memory deficits associated with AD. In addition, NAP was efficacious in an animal model of cholinotoxicity, enhancing performance in a water maze test following intranasal administration, an attractive drug application route. Further experiments identified NAP as neurotrophic, stimulating neurite outgrowth. These observations provide a potential basis for rational drug design against neurodegeneration with AL-108 (intranasal administered NAP) as the lead compound.",
keywords = "A-beta, ADNP, ApoE, Cholinotoxicity, NAP, Tau, Tubulin, VIP",
author = "I. Gozes",
year = "2006",
language = "אנגלית",
isbn = "2914377959",
series = "Research and Practice in Alzheimer's Disease",
pages = "392--395",
editor = "B. Vellas and E. Giacobini",
booktitle = "Research and Practice in Alzheimer's Disease",
}