Nanowired three-dimensional cardiac patches

Tal Dvir, Brian P. Timko, Mark D. Brigham, Shreesh R. Naik, Sandeep S. Karajanagi, Oren Levy, Hongwei Jin, Kevin K. Parker, Robert Langer, Daniel S. Kohane*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Engineered cardiac patches for treating damaged heart tissues after a heart attack are normally produced by seeding heart cells within three-dimensional porous biomaterial scaffolds1-3. These biomaterials, which are usually made of either biological polymers such as alginate4 or synthetic polymers such as poly(lactic acid) (PLA)5, help cells organize into functioning tissues, but poor conductivity of these materials limits the ability of the patch to contract strongly as a unit6. Here, we show that incorporating gold nanowires within alginate scaffolds can bridge the electrically resistant pore walls of alginate and improve electrical communication between adjacent cardiac cells. Tissues grown on these composite matrices were thicker and better aligned than those grown on pristine alginate and when electrically stimulated, the cells in these tissues contracted synchronously. Furthermore, higher levels of the proteins involved in muscle contraction and electrical coupling are detected in the composite matrices. It is expected that the integration of conducting nanowires within three-dimensional scaffolds may improve the therapeutic value of current cardiac patches.

Original languageEnglish
Pages (from-to)720-725
Number of pages6
JournalNature Nanotechnology
Issue number11
StatePublished - Nov 2011
Externally publishedYes


Dive into the research topics of 'Nanowired three-dimensional cardiac patches'. Together they form a unique fingerprint.

Cite this