Nanoarchitectonics of Small Molecule and DNA for Ultrasensitive Detection of Mercury

M. Pandeeswar, Satyaprasad P. Senanayak, T. Govindaraju*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Reliable and ultrasensitive detection of mercury ions is of paramount importance for toxicology assessment, environmental protection, and human health. Herein, we present a novel optoelectronic approach based on nanoarchitectonics of small-molecule templated DNA system that consists of an adenine (A)-conjugated small organic semiconductor (BNA) and deoxyribo-oligothymidine (dTn). This mutually templated dynamic chiral coassembly system (BNAn-dTn) with tunable chiroptical, morphological, and electrical properties is tapped in to enable ultrasensitive and selective detection of inorganic and organometallic mercury in water. We observe a rapid transformation of the BNAn-dTn coassembly into a metallo-DNA duplex [dT-Hg-dT]n in the presence of mercury, which is utilized for a chiro-optical and conductivity-based rapid and subnanomolar sensitivity (≥0.1 nM, 0.02 ppb) to mercury ions in water (∼100 times lower than United States Environmental Protection Agency tolerance limit). This ultrasensitive detection of inorganic and organometallic mercury is driven by a novel chemical design principle that allows strong mercury thymine interaction. This study is anticipated to inspire the development of future templated DNA nanotechnology-based optoelectronic devices for the rapid and ultrasensitive detection of numerous other toxic analytes.

Original languageEnglish
Pages (from-to)30362-30371
Number of pages10
JournalACS Applied Materials and Interfaces
Issue number44
StatePublished - 9 Nov 2016
Externally publishedYes


  • chiroptical and electrical detection
  • environmental pollutant
  • small organic semiconductor-DNA nanoarchitectonics
  • ultra sensitive detection of mercury


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