TY - JOUR
T1 - Naloxone reversal of endogenous opiates
T2 - paradoxical effect on humoral endorphin
AU - Sarne, Y.
AU - Gothilf, Yehoshua
AU - Avi Weissman, B.
PY - 1980
Y1 - 1980
N2 - Naloxone, a specific opiate antagonist, reverses the in vitro effect of morphine, enkaphalin and β-endorphin in the conventional concentration-dependent manner. However, naloxone affects the opioid activity of humoral endorphin, an endogenous substance present in blood, CSF and brain, in a paradoxical fashion: Low concentrations of naloxone antagonise the effect of humoral endorphin, while high concentrations fail to block, and even potentiate its opiate activity. This agonist-antagonist interaction sheds new light on conflicting results of experiments using naloxone antagonism as a criterion for the opioid nature of physiological mechanisms.
AB - Naloxone, a specific opiate antagonist, reverses the in vitro effect of morphine, enkaphalin and β-endorphin in the conventional concentration-dependent manner. However, naloxone affects the opioid activity of humoral endorphin, an endogenous substance present in blood, CSF and brain, in a paradoxical fashion: Low concentrations of naloxone antagonise the effect of humoral endorphin, while high concentrations fail to block, and even potentiate its opiate activity. This agonist-antagonist interaction sheds new light on conflicting results of experiments using naloxone antagonism as a criterion for the opioid nature of physiological mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=0019312364&partnerID=8YFLogxK
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AN - SCOPUS:0019312364
SN - 0155-7785
VL - 3
SP - 17
EP - 21
JO - Speculations in Science and Technology
JF - Speculations in Science and Technology
IS - 1
ER -