TY - JOUR
T1 - Naloxone is protective against indomethacin-induced intestinal ulceration in the rat
AU - Waisman, Y.
AU - Dinari, G.
AU - Marcus, H.
AU - Ligumsky, M.
AU - Rosenbach, Y.
AU - Zahavi, I.
AU - Nitzan, M.
PY - 1985/7
Y1 - 1985/7
N2 - Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats. We studied its possible protective effect against indomethacin-induced intestinal ulceration in the rat. Naloxone was indeed found to possess a marked protective effect on the intestinal mucosa (ulcer index 73.3 ± 13.6 vs. 273.8 ± 21.8, p < 0.001). Naloxone was found to elevate basal intestinal mucosal prostaglandin E2 (p < 0.001) and cyclic adenosine monophosphate levels (p < 0.005) but was unable to overcome the inhibition of prostaglandin E2 caused by indomethacin. An increase of cyclic adenosine monophosphate levels was seen, however, even in the presence of indomethacin, suggesting that cyclic adenosine monophosphate, but not prostaglandins, may play a role in the protective effect of naloxone.
AB - Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats. We studied its possible protective effect against indomethacin-induced intestinal ulceration in the rat. Naloxone was indeed found to possess a marked protective effect on the intestinal mucosa (ulcer index 73.3 ± 13.6 vs. 273.8 ± 21.8, p < 0.001). Naloxone was found to elevate basal intestinal mucosal prostaglandin E2 (p < 0.001) and cyclic adenosine monophosphate levels (p < 0.005) but was unable to overcome the inhibition of prostaglandin E2 caused by indomethacin. An increase of cyclic adenosine monophosphate levels was seen, however, even in the presence of indomethacin, suggesting that cyclic adenosine monophosphate, but not prostaglandins, may play a role in the protective effect of naloxone.
UR - http://www.scopus.com/inward/record.url?scp=0021863720&partnerID=8YFLogxK
U2 - 10.1016/0016-5085(85)90748-6
DO - 10.1016/0016-5085(85)90748-6
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AN - SCOPUS:0021863720
SN - 0016-5085
VL - 89
SP - 86
EP - 91
JO - Gastroenterology
JF - Gastroenterology
IS - 1
ER -