NADH Binds and stabilizes the 26S proteasomes independent of ATP

Peter Tsvetkov, Nadav Myers, Raz Eliav, Yaarit Adamovich, Tzachi Hagai, Julia Adler, Ami Navon, Yosef Shaul

Research output: Contribution to journalArticlepeer-review

Abstract

Background: 26S proteasome complex is highly dependent on ATP. Results: NADH binds the proteasome via the Psmc1 subunit resulting in ATP-independent stabilization of the 26S proteasome complex, in vitro and in cells. Conclusion: NADH is a novel regulator of the 26S proteasome. Significance: NADH can maintain proteasomal integrity in the absence of ATP, linking cellular redox state to protein degradation.

Original languageEnglish
Pages (from-to)11272-11281
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number16
DOIs
StatePublished - 18 Apr 2014
Externally publishedYes

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