@article{d0a55946e6344e82b94676e8bb60cba9,
title = "N-methyl-d-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stress-induced analgesia. I. Comparison of opiate receptor-deficient and opiate receptor-rich strains of mice",
abstract = "The effects of the specific N-methyl-d-aspartic acid (NMDA) receptor antagonist MK-801 (0.075 mg/kg), and the specific opiate receptor antagonist naloxone (10 mg/kg), on swim stress-induced analgesia (SSIA) were studied in opiate receptor-deficient (CXBK) and opiate receptor-rich (CXBH) mice. Animals were subjected to forced swimming, and analgesia was assessed using the hot-plate test. In CXBK mice SSIA was blocked by MK-801 but was completely insensitive to naloxone. In CXBH mice SSIA was partially attenuated both by naloxone and MK-801, and it was nearly abolished by a combination of these drugs. Morphine analgesia (10 mg/kg) was abolished by naloxone but completely unaffected by MK-801 in CXBH mice. These findings suggest that the NMDA receptor is critically involved in the non-opioid component of SSIA.",
keywords = "Excitatory amino acid, MK-801, N-Methyl-d-aspartate, Naloxone, Stress-induced analgesia",
author = "Przemyslaw Marek and Page, \{Gayle G.\} and Shamgar Ben-Eliyahu and Liebeskind, \{John C.\}",
note = "Funding Information: We wish to thank Mr. Herbert L. Washington and his staff for excellent care of animals. This study was supported by NIH Grant NS07628 and an Unrestricted Pain Research Grant from the Bristol-Myers Squibb Company.",
year = "1991",
month = jun,
day = "14",
doi = "10.1016/0006-8993(91)90943-P",
language = "אנגלית",
volume = "551",
pages = "293--296",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1-2",
}