N-methyl-d-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stress-induced analgesia. I. Comparison of opiate receptor-deficient and opiate receptor-rich strains of mice

Przemyslaw Marek, Gayle G. Page, Shamgar Ben-Eliyahu, John C. Liebeskind*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of the specific N-methyl-d-aspartic acid (NMDA) receptor antagonist MK-801 (0.075 mg/kg), and the specific opiate receptor antagonist naloxone (10 mg/kg), on swim stress-induced analgesia (SSIA) were studied in opiate receptor-deficient (CXBK) and opiate receptor-rich (CXBH) mice. Animals were subjected to forced swimming, and analgesia was assessed using the hot-plate test. In CXBK mice SSIA was blocked by MK-801 but was completely insensitive to naloxone. In CXBH mice SSIA was partially attenuated both by naloxone and MK-801, and it was nearly abolished by a combination of these drugs. Morphine analgesia (10 mg/kg) was abolished by naloxone but completely unaffected by MK-801 in CXBH mice. These findings suggest that the NMDA receptor is critically involved in the non-opioid component of SSIA.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalBrain Research
Volume551
Issue number1-2
DOIs
StatePublished - 14 Jun 1991
Externally publishedYes

Funding

FundersFunder number
National Institutes of Health
National Institute of Neurological Disorders and StrokeR01NS007628
Bristol-Myers Squibb

    Keywords

    • Excitatory amino acid
    • MK-801
    • N-Methyl-d-aspartate
    • Naloxone
    • Stress-induced analgesia

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