TY - JOUR
T1 - N-acetylcysteine use for amelioration of aminoglycoside-induced ototoxicity in dialysis patients
AU - Feldman, Leonid
AU - Sherman, Richard A.
AU - Weissgarten, Joshua
PY - 2012/9
Y1 - 2012/9
N2 - Use of aminoglycoside antibiotics is associated with significant ototoxicity, especially on patients with decreased renal function. The risk of aminoglycoside ototoxicity may approach 60%. Oxidative stress has been suggested as a general mechanism of aminoglycoside ototoxicity and is prevalent in dialysis population. N-acetylcysteine (NAC) is an effective antioxidant and has been safely used in dialysis patients. New experimental and clinical data, explored in this review, provide a good case to recommend NAC administration to all dialysis patients, receiving aminoglycosides.
AB - Use of aminoglycoside antibiotics is associated with significant ototoxicity, especially on patients with decreased renal function. The risk of aminoglycoside ototoxicity may approach 60%. Oxidative stress has been suggested as a general mechanism of aminoglycoside ototoxicity and is prevalent in dialysis population. N-acetylcysteine (NAC) is an effective antioxidant and has been safely used in dialysis patients. New experimental and clinical data, explored in this review, provide a good case to recommend NAC administration to all dialysis patients, receiving aminoglycosides.
UR - http://www.scopus.com/inward/record.url?scp=84866545236&partnerID=8YFLogxK
U2 - 10.1111/j.1525-139X.2012.01090.x
DO - 10.1111/j.1525-139X.2012.01090.x
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C2 - 22708712
AN - SCOPUS:84866545236
SN - 0894-0959
VL - 25
SP - 491
EP - 494
JO - Seminars in Dialysis
JF - Seminars in Dialysis
IS - 5
ER -