N-acetylcysteine use for amelioration of aminoglycoside-induced ototoxicity in dialysis patients

Leonid Feldman*, Richard A. Sherman, Joshua Weissgarten

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Use of aminoglycoside antibiotics is associated with significant ototoxicity, especially on patients with decreased renal function. The risk of aminoglycoside ototoxicity may approach 60%. Oxidative stress has been suggested as a general mechanism of aminoglycoside ototoxicity and is prevalent in dialysis population. N-acetylcysteine (NAC) is an effective antioxidant and has been safely used in dialysis patients. New experimental and clinical data, explored in this review, provide a good case to recommend NAC administration to all dialysis patients, receiving aminoglycosides.

Original languageEnglish
Pages (from-to)491-494
Number of pages4
JournalSeminars in Dialysis
Volume25
Issue number5
DOIs
StatePublished - Sep 2012

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