N-acetylcysteine improves residual renal function in peritoneal dialysis patients: A pilot study

Leonid Feldman*, Michal Shani, Shai Efrati, Ilia Beberashvili, Iris Yakov-Hai, Elena Abramov, Inna Sinuani, Roza Rosenberg, Joshua Weissgarten

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Preservation of peritoneal membrane function and residual renal function is important for the optimal care of peritoneal dialysis patients. N-Acetyl- cysteine may ameliorate oxidative stress, which is thought to be involved in peritoneal membrane dysfunction. In addition, N--acetylcysteine may have a positive effect on renal function in the setting of nephrotoxic contrast media administration. The aim of this study was to investigate the effect of N-acetylcysteine on peritoneal and residual renal function in peritoneal dialysis patients. Methods: Ten prevalent peritoneal dialysis patients were administered oral N-acetylcysteine 1200 mg twice daily for 4 weeks. At baseline and at the end of treatment, peritoneal membrane function and residual renal function were assessed using a 4.25% dextrose peritoneal equilibration test and 24-hour dialysate and urine collection for calculation of peritoneal and residual renal Kt/V and mean urea and creatinine residual renal clearance. Results: No significant changes were demonstrated in peritoneal membrane function, including dialysate-to-plasma creatinine ratio, sodium sieving, and net ultrafiltration. Residual renal function improved significantly: urine volume increased from 633 ± 426 to 925 ± 552 mL/24 hours (p = 0.022), residual renal Kt/V increased from 0.56 ± 0.41 to 0.75 ± 0.47 (p = 0.037), and mean residual urea and creatinine clearance increased from 4.96 ± 3.96 to 5.95 ± 4.08 mL/min/1.73 m 2 (p = 0.059). Conclusions: N-acetylcysteine may improve residual renal function in patients treated with peritoneal dialysis.

Original languageEnglish
Pages (from-to)545-550
Number of pages6
JournalPeritoneal Dialysis International
Issue number5
StatePublished - Sep 2011


  • N-Acetylcysteine
  • Residual renal function


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