n - 3 phosphatidylserine attenuated scopolamine-induced amnesia in middle-aged rats

Nachum Vaisman, Dori Pelled

Research output: Contribution to journalArticlepeer-review


Phosphatidylserine (PS) extracted from bovine brain differs from transphosphatidylated soybean lecithin PS (SB-PS) in its n - 3 long-chain polyunsaturated fatty acid (LC-PUFA) content. Both, however, were suggested to affect cognitive performance. We compared the effect of chronic administration of a novel n - 3 LC-PUFA PS conjugates (n - 3 PS) versus SB-PS, fish oil (FO), SB-PS + FO, or control oil in middle-aged rats, on brain fatty acids composition and performance in behavioral tasks. Our hypothesis was that the n - 3 LC-PUFA vehicles will affect these outcomes better than the other diets. Brain phospholipid docosahexaenoic acid levels increased significantly (p = 0.0434) with n - 3 PS only. None of the treatments affected the animals' task performance in compare with the control, although reversal from the non-match-to-sample to match-to-sample rule in the T-maze differed (p = 0.0434) between the experimental diets. Conversely, the acquisition of the Morris water maze task was impaired by scopolamine (SCO) in all but the n - 3 PS group (p = 0.0019). In the probe, when pretreated with SCO, the SB-PS + FO group and to a lesser degree the n - 3 PS group, spent longer latency times (p = 0.0390) in the non-peripheral zones of the water maze compared to the control; this may be interpreted as anxiolytic-like behavior. These results suggest that the n - 3 LC-PUFA carrier may play a role in these fatty acids bioavailability and their impact on specific cognitive processes.

Original languageEnglish
Pages (from-to)952-959
Number of pages8
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number6
StatePublished - 31 Aug 2009
Externally publishedYes


  • Behavior
  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Memory
  • Phospholipids


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