Néoplasie intraépithéliale prostatique de haut grade: detection et association avec le cancer de la prostate.

G. Raviv; T. Janssen; A. R. Zlotta; L. Louis; F. Descamps; A. Verhest; C. C. Schulman

Néoplasie intraépithéliale prostatique de haut grade: detection et association avec le cancer de la prostate.

Translated title of the contribution: High-grade intraepithelial prostatic neoplasms: diagnosis and association with prostate cancer

G. Raviv^*, T. Janssen, A. R. Zlotta, L. Louis, F. Descamps, A. Verhest, C. C. Schulman

^*Corresponding author for this work

Université libre de Bruxelles

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Prostatic intraepithelial neoplasia (PIN) fulfils the majority of requirements for a premalignant change in the human prostate. Forty-eight patients were diagnosed to have high grade PIN on prostatic needle biopsy. During a follow-up period, 23 (47.9%) were found to have adenocarcinoma on subsequent biopsies. We compared the patients age, the digital examination, the transrectal ultrasound appearance (TRUS) and the serum PSA level between those in whom cancer was detected subsequently and those with PIN alone. There was a statistically significant difference in the transrectal ultrasound appearance (TRUS) and the serum PSA level between the two groups (p < 0.001, p < 0.016 respectively). In conclusion, patients with high grade PIN, elevated serum PSA with hypoechoic zone on TRUS should be rebiopsied 3 months after the initial diagnosis. If the results are negative, close follow-up is mandatory.

Translated title of the contribution	High-grade intraepithelial prostatic neoplasms: diagnosis and association with prostate cancer
Original language	French
Pages (from-to)	11-15
Number of pages	5
Journal	Acta Urologica Belgica
Volume	64
Issue number	1
State	Published - Mar 1996
Externally published	Yes

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Cite this

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title = "N{\'e}oplasie intra{\'e}pith{\'e}liale prostatique de haut grade: detection et association avec le cancer de la prostate.",

abstract = "Prostatic intraepithelial neoplasia (PIN) fulfils the majority of requirements for a premalignant change in the human prostate. Forty-eight patients were diagnosed to have high grade PIN on prostatic needle biopsy. During a follow-up period, 23 (47.9%) were found to have adenocarcinoma on subsequent biopsies. We compared the patients age, the digital examination, the transrectal ultrasound appearance (TRUS) and the serum PSA level between those in whom cancer was detected subsequently and those with PIN alone. There was a statistically significant difference in the transrectal ultrasound appearance (TRUS) and the serum PSA level between the two groups (p < 0.001, p < 0.016 respectively). In conclusion, patients with high grade PIN, elevated serum PSA with hypoechoic zone on TRUS should be rebiopsied 3 months after the initial diagnosis. If the results are negative, close follow-up is mandatory.",

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T2 - detection et association avec le cancer de la prostate.

AU - Raviv, G.

AU - Janssen, T.

AU - Zlotta, A. R.

AU - Louis, L.

AU - Descamps, F.

AU - Verhest, A.

AU - Schulman, C. C.

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AB - Prostatic intraepithelial neoplasia (PIN) fulfils the majority of requirements for a premalignant change in the human prostate. Forty-eight patients were diagnosed to have high grade PIN on prostatic needle biopsy. During a follow-up period, 23 (47.9%) were found to have adenocarcinoma on subsequent biopsies. We compared the patients age, the digital examination, the transrectal ultrasound appearance (TRUS) and the serum PSA level between those in whom cancer was detected subsequently and those with PIN alone. There was a statistically significant difference in the transrectal ultrasound appearance (TRUS) and the serum PSA level between the two groups (p < 0.001, p < 0.016 respectively). In conclusion, patients with high grade PIN, elevated serum PSA with hypoechoic zone on TRUS should be rebiopsied 3 months after the initial diagnosis. If the results are negative, close follow-up is mandatory.

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Néoplasie intraépithéliale prostatique de haut grade: detection et association avec le cancer de la prostate.

Abstract

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