TY - JOUR
T1 - Myocardial ultrasonic backscatter for characterization of ischemia and reperfusion
T2 - relationship to wall motion
AU - Barzilai, Benico
AU - Vered, Zvi
AU - Mohr, G. A.
AU - Wear, Keith A.
AU - Courtois, Michael
AU - Sobel, Burton E.
AU - Miller, James G.
AU - Pérez, Julio E.
N1 - Funding Information:
Acknowledgements--Supported in part by National Institutes of Health Grants HL-17646 SCOR in lschemic Heart Disease and R01 HL-39063 and HL-40302 and the U.S.A.-Israel Binational Science Foundation. We thank Donald W. Myears, M.D. for his assistance with the measurement of blood flow by microspheres.
PY - 1990
Y1 - 1990
N2 - We have previously shown that cardiac cycle-dependent variation of integrated backscatter occurs in normal myocardium. To determine whether myocardial ischemia and reperfusion can be distinguished by real-time integrated backscatter imaging we performed 10 min balloon occlusion of the Left Anterior Descending (LAD) coronary artery followed by reperfusion in 10 closed-chest anesthetized dogs. Images were obtained at baseline, during occlusion, and up to 120 min after reperfusion. We measured the magnitude and delay of cyclic variation of integrated backscatter in segments with and without asynergy. Radiolabeled microspheres were used to verify both ischemia and reperfusion. Ischemic segments exhibited decreased magnitude and increased normalized delay of cyclic variation of integrated backscatter (from 3.3± 0.3 dB to 1.4 ± 0.2 dB, mean ± SE; and from 0.95 ± 0.03 to 1.67 ± 0.15, respectively, all p ≤ 0.001). Reperfusion promptly restored the magnitude of cyclic variation toward normal. However, the delay of the cyclic variation was restored only partially. Wall motion analysis of the ischemic sites revealed persistent abnormalities throughout the reperfusion interval despite return to normal of the magnitude and delay of cyclic variation. Thus, real-time integrated backscatter imaging permits detection and differentiation of changes in myocardial acoustic properties indicative of ischemia and of subsequent reperfusion.
AB - We have previously shown that cardiac cycle-dependent variation of integrated backscatter occurs in normal myocardium. To determine whether myocardial ischemia and reperfusion can be distinguished by real-time integrated backscatter imaging we performed 10 min balloon occlusion of the Left Anterior Descending (LAD) coronary artery followed by reperfusion in 10 closed-chest anesthetized dogs. Images were obtained at baseline, during occlusion, and up to 120 min after reperfusion. We measured the magnitude and delay of cyclic variation of integrated backscatter in segments with and without asynergy. Radiolabeled microspheres were used to verify both ischemia and reperfusion. Ischemic segments exhibited decreased magnitude and increased normalized delay of cyclic variation of integrated backscatter (from 3.3± 0.3 dB to 1.4 ± 0.2 dB, mean ± SE; and from 0.95 ± 0.03 to 1.67 ± 0.15, respectively, all p ≤ 0.001). Reperfusion promptly restored the magnitude of cyclic variation toward normal. However, the delay of the cyclic variation was restored only partially. Wall motion analysis of the ischemic sites revealed persistent abnormalities throughout the reperfusion interval despite return to normal of the magnitude and delay of cyclic variation. Thus, real-time integrated backscatter imaging permits detection and differentiation of changes in myocardial acoustic properties indicative of ischemia and of subsequent reperfusion.
KW - Echocardiography
KW - Integrated backscatter
KW - Myocardial reperfusion
KW - Ultrasonic tissue characterization
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=0025352019&partnerID=8YFLogxK
U2 - 10.1016/0301-5629(90)90068-N
DO - 10.1016/0301-5629(90)90068-N
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AN - SCOPUS:0025352019
SN - 0301-5629
VL - 16
SP - 391
EP - 398
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 4
ER -