TY - JOUR
T1 - Myocardial tissue engineering
T2 - Creating a muscle patch for a wounded heart
AU - Leor, Jonathan
AU - Cohen, Smadar
PY - 2004
Y1 - 2004
N2 - Cardiac tissue engineering promises to revolutionize the treatment of patients with end-stage heart failure and provide new solutions to the serious problem of heart donor shortage. By its broad definition, tissue engineering involves the construction of tissue equivalents from donor cells seeded within three-dimensional polymeric scaffolds, then culturing and implanting of the cell-seeded scaffolds to induce and direct the growth of new, healthy tissue. Here, we present an up-to-date summary of research studies in cardiac tissue engineering, with an emphasis on the critical design principles.
AB - Cardiac tissue engineering promises to revolutionize the treatment of patients with end-stage heart failure and provide new solutions to the serious problem of heart donor shortage. By its broad definition, tissue engineering involves the construction of tissue equivalents from donor cells seeded within three-dimensional polymeric scaffolds, then culturing and implanting of the cell-seeded scaffolds to induce and direct the growth of new, healthy tissue. Here, we present an up-to-date summary of research studies in cardiac tissue engineering, with an emphasis on the critical design principles.
KW - Biomaterial
KW - Cell
KW - Heart
KW - Three-dimensional scaffold
UR - http://www.scopus.com/inward/record.url?scp=3042709047&partnerID=8YFLogxK
U2 - 10.1196/annals.1302.026
DO - 10.1196/annals.1302.026
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AN - SCOPUS:3042709047
SN - 0077-8923
VL - 1015
SP - 312
EP - 319
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -