Myocardial tissue characterization: Clinical confirmation of laboratory results

James G. Miller*, Benico Barzilai, Mark R. Milunski, Gregory A. Mohr, Julio E. Perez, Lewis J. Thomas, Keith A. Wear, Samuel A. Wickline, Zvi Vered, Burton E. Sobel

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Tissue characterization previously identified ischemia, infarction, and cardiomyopathy in animal myocardium. Investigations to determine whether analogous results occur in patients were undertaken with a real-time two-dimensional backscatter imaging system. Remote infarction in 15 patients was accompanied by reduced magnitude and delayed cyclic variation. Similarly, ultrasonic evidence of diminished contractile function was found in five patients with dilated cardiomyopathy compared to 15 patients in a control group. Studies of 15 patients with acute myocardial infarction indicate that tissue characterization may permit the detection of reversibly injured or 'stunned' myocardium, despite the presence of severe wall-motion abnormalities that might otherwise mask the presence of viable but transiently dysfunctional tissue.

Original languageEnglish
Pages (from-to)1029-1036
Number of pages8
Journal[No source information available]
StatePublished - 1989
Externally publishedYes
EventIEEE 1989 Ultrasonics Symposium - Montreal, Que, Can
Duration: 3 Oct 19896 Oct 1989


Dive into the research topics of 'Myocardial tissue characterization: Clinical confirmation of laboratory results'. Together they form a unique fingerprint.

Cite this