Myocardial repair: From salvage to tissue reconstruction

Emil Ruvinov*, Tal Dvir, Jonathan Leor, Smadar Cohen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cardiac tissue reconstruction following myocardial infarction represents a major challenge in cardiovascular therapy, as current clinical approaches are limited in their ability to regenerate or replace damaged myocardium. Thus, different novel treatments have been introduced aimed at myocardial salvage and repair. Here, we present a review of recent advancements in cardiac cell, gene-based and tissue engineering therapies. Selected strategies in cell therapy and new tools for myocardial gene transfer are summarized. Finally, we consider novel approaches to myocardial tissue engineering as a platform for the integration of various modalities in an attempt to rejuvenate infarcted tissue in vivo.

Original languageEnglish
Pages (from-to)669-686
Number of pages18
JournalExpert Review of Cardiovascular Therapy
Volume6
Issue number5
DOIs
StatePublished - Jun 2008

Funding

FundersFunder number
Israel Science Foundation793/04
Ben-Gurion University of the Negev

    Keywords

    • Biomaterial
    • Cell therapy
    • Gene therapy
    • Heart
    • Myocardial regeneration
    • Tissue engineering

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