Myocardial ischemia induced by topical use of 5-fluorouracil

Yoseph Rozenman*, Joseph Gurewich, Mervyn S. Gotsman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


An 85-year-old woman, with known stable angina pectoris, was prescribed 5-fluorouracil cream to treat a small basal cell carcinoma on the forehead. Half an hour after application the patient developed her typical ischemic pain which persisted for 2 hours. Rechallenge, during hospitalization, resulted in recurrence of symptoms that were effectively controlled with sublingual isosorbide dinitrate. Prophylactic therapy with nitroglycerin patch enabled further use of the 5-fluorouracil cream for the next month.

Original languageEnglish
Pages (from-to)282-283
Number of pages2
JournalInternational Journal of Cardiology
Issue number3
StatePublished - May 1995
Externally publishedYes


  • 5-fluorouracil
  • Cardiotoxicity
  • Coronary spasm
  • Nitrates


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