@article{5713f4bd6b1e4cfebc5e48163ec1b2eb,
title = "Myocardial contrast echocardiography: Influence of ischaemia and hyperaemia in an animal model",
abstract = "To evaluate changes in myocardial contrast echocardiography during ischaemia and hyperaemia, contrast studies were performed in 16 open chest dogs. Time-intensity curves were generated using videodensitometry after contrast injections to demonstrate ischaemic and non-ischaemic areas of interest during a wide range of coronary blood flow levels. For each time-intensity curve, the peak contrast intensity (PCI), washout halftime (T1/22) and area under the curve (AUC) were calculated. PCI and AUC decreased significantly only with severe ischaemia (90% or more reduction in flow), and increased significantly with hyperaemia of more than 2.5 times baseline flow. Both ischaemia and hyperaemia were found to prolong the T1/2. There was only a moderate linear correlation between the magnitude of hyperaemia and myocardial contrast echocardiographic parameters. There was significantly less increase in myocardial contrast echocardiographic parameters during hyperaemia in segments supplied by a stenosed coronary artery.",
keywords = "Contrast echocardiography, Echocardiography, Hyperemia, Ischaemia",
author = "Reisner, {S. A.} and S. Gottlieb and A. Ernst and Shapiro, {J. R.} and R. Beyar and W. Markiewicz and Meltzer, {R. S.}",
note = "Funding Information: This work was supported in part by a United States-Israel Binational Science Foundation Grant (88-00177) lo Dr Reisner.",
year = "1992",
doi = "10.1093/oxfordjournals.eurheartj.a060178",
language = "אנגלית",
volume = "13",
pages = "383--388",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "3",
}