Myocardial contrast echocardiography: Influence of ischaemia and hyperaemia in an animal model

S. A. Reisner*, S. Gottlieb, A. Ernst, J. R. Shapiro, R. Beyar, W. Markiewicz, R. S. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


To evaluate changes in myocardial contrast echocardiography during ischaemia and hyperaemia, contrast studies were performed in 16 open chest dogs. Time-intensity curves were generated using videodensitometry after contrast injections to demonstrate ischaemic and non-ischaemic areas of interest during a wide range of coronary blood flow levels. For each time-intensity curve, the peak contrast intensity (PCI), washout halftime (T1/22) and area under the curve (AUC) were calculated. PCI and AUC decreased significantly only with severe ischaemia (90% or more reduction in flow), and increased significantly with hyperaemia of more than 2.5 times baseline flow. Both ischaemia and hyperaemia were found to prolong the T1/2. There was only a moderate linear correlation between the magnitude of hyperaemia and myocardial contrast echocardiographic parameters. There was significantly less increase in myocardial contrast echocardiographic parameters during hyperaemia in segments supplied by a stenosed coronary artery.

Original languageEnglish
Pages (from-to)383-388
Number of pages6
JournalEuropean Heart Journal
Issue number3
StatePublished - 1992
Externally publishedYes


FundersFunder number
United States-Israel Binational Science Foundation88-00177


    • Contrast echocardiography
    • Echocardiography
    • Hyperemia
    • Ischaemia


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