TY - JOUR
T1 - Myocardial contractility and left ventricular function in obese patients with essential hypertension
AU - Garavaglia, Guillermo E.
AU - Messerli, Franz H.
AU - Nunez, Boris D.
AU - Schmieder, Roland E.
AU - Grossman, Ehud
N1 - Funding Information:
From the Department of Internal Medicine, Section on Hypertensive Diseases, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, Louisiana. Dr. Schmieder was supported in part by a grant from Deutsche Forschungsgemeinschaft, Federal Republic of Germany; present address: Department of Medicine, University of Bonn, Sigmund Freudstrasse 25, D 5300 Bonn-Venusberg, Federal Republic of Germany. Manuscript received July 17, 19871 revised manuscript received May 6, 1988, and accepted May 16.
PY - 1988/9/15
Y1 - 1988/9/15
N2 - Although the risk of developing congestive heart failure increases in parallel with the degree of obesity, load-dependent indexes of left ventricular function are found to be reduced in patients with morbid obesity only. We used the ratio of end-systolic wall stress to end-systolic volume index, which is load-independent, to assess myocardial contractility in 23 nonobese, 28 mildly obese and 26 moderately obese patients with mild to moderate essential hypertension. Although load-dependent indexes (i.e., ejection fraction, fractional fiber shortening and velocity of circumferential fiber shortening) were similar in the 3 groups, end-systolic wall stress to end-systolic volume index was lower in the moderately obese group (2.63 ± 0.4, p < 0.002) and even in the mildly obese group (2.88 ± 0.8, p < 0.05) than in the nonobese group (3.27 ± 0.7). Further, there was a significant inverse relation between end-systolic wall stress to end-systolic volume index and body mass index (r = -0.34, p < 0.005), diastolic diameter (r = -0.56, p < 0.001) and left ventricular mass index (r = -0.55, p < 0.001). Some obese patients have depressed myocardial contractility when compared with lean patients despite well-preserved pump function.
AB - Although the risk of developing congestive heart failure increases in parallel with the degree of obesity, load-dependent indexes of left ventricular function are found to be reduced in patients with morbid obesity only. We used the ratio of end-systolic wall stress to end-systolic volume index, which is load-independent, to assess myocardial contractility in 23 nonobese, 28 mildly obese and 26 moderately obese patients with mild to moderate essential hypertension. Although load-dependent indexes (i.e., ejection fraction, fractional fiber shortening and velocity of circumferential fiber shortening) were similar in the 3 groups, end-systolic wall stress to end-systolic volume index was lower in the moderately obese group (2.63 ± 0.4, p < 0.002) and even in the mildly obese group (2.88 ± 0.8, p < 0.05) than in the nonobese group (3.27 ± 0.7). Further, there was a significant inverse relation between end-systolic wall stress to end-systolic volume index and body mass index (r = -0.34, p < 0.005), diastolic diameter (r = -0.56, p < 0.001) and left ventricular mass index (r = -0.55, p < 0.001). Some obese patients have depressed myocardial contractility when compared with lean patients despite well-preserved pump function.
UR - http://www.scopus.com/inward/record.url?scp=0023751196&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(88)90662-5
DO - 10.1016/0002-9149(88)90662-5
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AN - SCOPUS:0023751196
SN - 0002-9149
VL - 62
SP - 594
EP - 597
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 9
ER -
