Myeloschisis in a six weeks embryo of a leukemic woman treated by busulfan

A. Abramovici*, M. Shaklai, J. Pinkhas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A case of myeloschisis in a six weeks old human embryo is reported. The 39‐year‐old mother was treated by busulfan before and during the early stages of gestation for chronic lymphatic leukemia. Additional histological findings consisted in a decrease of mesenchymal elements together with a somitic disorganisation in the affected area of the embryo. In spite of the well known experience that this drug is well tolerated by leukemic pregnant women, a possible interference of busulfan with the oocyte differentiation in this elderly primipara is proposed.

Original languageEnglish
Pages (from-to)241-245
Number of pages5
Issue number2
StatePublished - Oct 1978


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