Myelin‐ and microbe‐specific antibodies in guillain‐barré syndrome

Jeff Terryberry, Made Sutjita, Yehuda Shoenfeld, Boris Gilburd, David Tanne, Margalit Lorber, Iyad Alosachie, Noori Barka, Hun‐Chi ‐C Lin, Pierre Youinou, James B. Peter

Research output: Contribution to journalArticlepeer-review

Abstract

We surveyed the frequency of reported infections and target autoantigens in 56 Guillain Barré syndrome (GBS) patients by detecting antibodies to myelin and microbes. Sulfatide (43%), cardiolipin (48%), GD1a (15%), SGPG (11%), and GM3 (11%) antibodies were the most frequently detected heterogenous autoantibodies. A wide spectrum of antimicrobial IgG and IgM antibodies were also detected; mumps‐specific IgG (66%), adenovirus‐specific IgG (52%), varicella‐zoster virus‐specific IgG (46%), and S. pneumoniae serotype 7‐specific IgG (45%) were the most prevalent. Our results indicate that polyclonal expansion of physiologic and pathologic antibodies and/or molecular mimicry likely occurs following infection and is related to other autoimmune factors in the etiology of GBS. Although no single definitive myelin‐specific autoantibody was identified, our results suggest a unique pattern of reactivity against autoantigens.

Original languageEnglish
Pages (from-to)308-319
Number of pages12
JournalJournal of Clinical Laboratory Analysis
Volume9
Issue number5
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • autoantibodies
  • autoimmunity
  • gangliosides
  • myelin
  • neuropathy

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