Abstract
Male albino rats, injected intravenously or intracerebroventricularly with Δ1-tetrahydrocannabinol (THC), develope mydriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 μg/kg THC. Sympathectomy significantly decreased the THC-induced mydriasis. The mydriatic effect was not influenced by naloxone. We conclude that THC produces mydriasis through a central action, the efferent pathway of which is the sympathetic system.
| Original language | English |
|---|---|
| Pages (from-to) | 408-410 |
| Number of pages | 3 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 22 |
| Issue number | 3 |
| State | Published - 1982 |