Mydriasis induced by tetrahydrocannabinol (THC) in rats

Y. Eshel, A. D. Korczyn

Research output: Contribution to journalArticlepeer-review


Male albino rats, injected intravenously or intracerebroventricularly with Δ1-tetrahydrocannabinol (THC), develope mydriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 μg/kg THC. Sympathectomy significantly decreased the THC-induced mydriasis. The mydriatic effect was not influenced by naloxone. We conclude that THC produces mydriasis through a central action, the efferent pathway of which is the sympathetic system.

Original languageEnglish
Pages (from-to)408-410
Number of pages3
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - 1982


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