TY - JOUR
T1 - My personal mutanome
T2 - a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype
AU - Zhou, Yadi
AU - Zhao, Junfei
AU - Fang, Jiansong
AU - Martin, William
AU - Li, Lang
AU - Nussinov, Ruth
AU - Chan, Timothy A.
AU - Eng, Charis
AU - Cheng, Feixiong
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Massive genome sequencing data have inspired new challenges in personalized treatments and facilitated oncological drug discovery. We present a comprehensive database, My Personal Mutanome (MPM), for accelerating the development of precision cancer medicine protocols. MPM contains 490,245 mutations from over 10,800 tumor exomes across 33 cancer types in The Cancer Genome Atlas mapped to 94,563 structure-resolved/predicted protein-protein interaction interfaces (“edgetic”) and 311,022 functional sites (“nodetic”), including ligand-protein binding sites and 8 types of protein posttranslational modifications. In total, 8884 survival results and 1,271,132 drug responses are obtained for these mapped interactions. MPM is available at https://mutanome.lerner.ccf.org.
AB - Massive genome sequencing data have inspired new challenges in personalized treatments and facilitated oncological drug discovery. We present a comprehensive database, My Personal Mutanome (MPM), for accelerating the development of precision cancer medicine protocols. MPM contains 490,245 mutations from over 10,800 tumor exomes across 33 cancer types in The Cancer Genome Atlas mapped to 94,563 structure-resolved/predicted protein-protein interaction interfaces (“edgetic”) and 311,022 functional sites (“nodetic”), including ligand-protein binding sites and 8 types of protein posttranslational modifications. In total, 8884 survival results and 1,271,132 drug responses are obtained for these mapped interactions. MPM is available at https://mutanome.lerner.ccf.org.
KW - Edgetic
KW - Mutanome
KW - Nodetic
KW - Precision cancer medicine
KW - Protein-protein interaction
KW - Somatic mutations
UR - http://www.scopus.com/inward/record.url?scp=85100077586&partnerID=8YFLogxK
U2 - 10.1186/s13059-021-02269-3
DO - 10.1186/s13059-021-02269-3
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 33514395
AN - SCOPUS:85100077586
SN - 1474-7596
VL - 22
JO - Genome Biology
JF - Genome Biology
IS - 1
M1 - 53
ER -
