TY - JOUR
T1 - Mutations of the MYH gene do not substantially contribute to the risk of breast cancer
AU - Beiner, Mario E.
AU - Zhang, William W.
AU - Zhang, Shiyu
AU - Gallinger, Steven
AU - Sun, Ping
AU - Narod, Steven A.
PY - 2009/4
Y1 - 2009/4
N2 - Purpose To explore whether or not there is an association between the presence of either of the germline mutations in the MutY human homologue (MYH) gene (Y165C and G382D) and the risk of breast cancer. Methods 691 breast cancer patients and 812 healthy controls were genotyped for the MYH Y165C and G382D mutations. The frequencies of heterozygotes, homozygotes and compound heterozygotes were compared for the two groups. Results Four (0.6%) of 691 breast cancer cases carried a MYH Y165C mutant allele, compared to five (0.6%) of the controls (OR 1.1, 95%CI 0.29-4.0, P = 0.9). Eight (1.2%) cases carried a MYH G382D mutant allele, compared to eight (1.0%) of the controls (OR 1.2, 95%CI 0.44-3.3, P = 0.7). No case or control was homozygous for the variant and none were compound heterozygotes. Conclusion Carriers of the MYH Y165C or G382D mutant alleles do not appear to be at increased risk for breast cancer.
AB - Purpose To explore whether or not there is an association between the presence of either of the germline mutations in the MutY human homologue (MYH) gene (Y165C and G382D) and the risk of breast cancer. Methods 691 breast cancer patients and 812 healthy controls were genotyped for the MYH Y165C and G382D mutations. The frequencies of heterozygotes, homozygotes and compound heterozygotes were compared for the two groups. Results Four (0.6%) of 691 breast cancer cases carried a MYH Y165C mutant allele, compared to five (0.6%) of the controls (OR 1.1, 95%CI 0.29-4.0, P = 0.9). Eight (1.2%) cases carried a MYH G382D mutant allele, compared to eight (1.0%) of the controls (OR 1.2, 95%CI 0.44-3.3, P = 0.7). No case or control was homozygous for the variant and none were compound heterozygotes. Conclusion Carriers of the MYH Y165C or G382D mutant alleles do not appear to be at increased risk for breast cancer.
KW - Association
KW - Breast cancer
KW - MYH
UR - http://www.scopus.com/inward/record.url?scp=61449234294&partnerID=8YFLogxK
U2 - 10.1007/s10549-008-0042-1
DO - 10.1007/s10549-008-0042-1
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C2 - 18454351
AN - SCOPUS:61449234294
SN - 0167-6806
VL - 114
SP - 575
EP - 578
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
IS - 3
ER -
