Mutagenic induction of an ultra-fast water-chain proton wire

Vered Wineman-Fisher, Ron Simkovich, Dan Huppert, Kristina Trujillo, S. James Remington, Yifat Miller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Replacement of the hydroxyl group of a hydrophilic sidechain by an H atom in the proton wire of GFP induces formation of a water-chain proton wire. Surprisingly, this "non-native" water chain functions as a proton wire with response times within 10 ps of the wild type protein. This remarkable rate retention is understood as a natural consequence of the well-known Grotthuss mechanism of proton transfer in water.

Original languageEnglish
Pages (from-to)23089-23095
Number of pages7
JournalPhysical Chemistry Chemical Physics
Issue number33
StatePublished - 2016


FundersFunder number
Directorate for Biological Sciences1021374


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