TY - JOUR
T1 - Mutagenesis in Streptococcus pneumoniae (Pneumococcus) by transformation with DNA modified by the carcinogen-mutagen, aflatoxin B1
AU - Stark, Avishay A.
AU - Giroux, Craig N.
PY - 1983/1
Y1 - 1983/1
N2 - Covalent binding of metabolically activated aflatoxin B1 (AFB1) to transforming DNA of Pneumococcus caused a decrease in transforming activity and induced mutations to antibiotic resistance in recipients. The 2 effects were proportional, in vitro, to the covalent bnding levels of AFB1 to pneumococcal DNA.
AB - Covalent binding of metabolically activated aflatoxin B1 (AFB1) to transforming DNA of Pneumococcus caused a decrease in transforming activity and induced mutations to antibiotic resistance in recipients. The 2 effects were proportional, in vitro, to the covalent bnding levels of AFB1 to pneumococcal DNA.
UR - http://www.scopus.com/inward/record.url?scp=0020659015&partnerID=8YFLogxK
U2 - 10.1016/0027-5107(83)90075-1
DO - 10.1016/0027-5107(83)90075-1
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AN - SCOPUS:0020659015
SN - 0027-5107
VL - 107
SP - 23
EP - 32
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 1
ER -