TY - JOUR
T1 - Multispectral sensing of biological liquids with hollow-core microstructured optical fibres
AU - Ermatov, Timur
AU - Noskov, Roman E.
AU - Machnev, Andrey A.
AU - Gnusov, Ivan
AU - Аtkin, Vsevolod
AU - Lazareva, Ekaterina N.
AU - German, Sergei V.
AU - Kosolobov, Sergey S.
AU - Zatsepin, Timofei S.
AU - Sergeeva, Olga V.
AU - Skibina, Julia S.
AU - Ginzburg, Pavel
AU - Tuchin, Valery V.
AU - Lagoudakis, Pavlos G.
AU - Gorin, Dmitry A.
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance. This common strategy, however, disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral domain. Here, we address this issue by introducing the approach of in-fibre multispectral optical sensing (IMOS). The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells. IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths, with a sensitivity up to ~3000 nm per refractive index unit (RIU) and a figure of merit reaching 99 RIU−1 in the visible and near-infra-red spectral ranges. We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.
AB - The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance. This common strategy, however, disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral domain. Here, we address this issue by introducing the approach of in-fibre multispectral optical sensing (IMOS). The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells. IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths, with a sensitivity up to ~3000 nm per refractive index unit (RIU) and a figure of merit reaching 99 RIU−1 in the visible and near-infra-red spectral ranges. We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.
UR - http://www.scopus.com/inward/record.url?scp=85092342135&partnerID=8YFLogxK
U2 - 10.1038/s41377-020-00410-8
DO - 10.1038/s41377-020-00410-8
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C2 - 33082942
AN - SCOPUS:85092342135
SN - 2095-5545
VL - 9
JO - Light: Science and Applications
JF - Light: Science and Applications
IS - 1
M1 - 173
ER -