TY - GEN
T1 - Multiprot-a multiple protein structural alignment algorithm
AU - Shatsky, Maxim
AU - Nussinov, Ruth
AU - Wolfson, Haim J.
N1 - Publisher Copyright:
© Springer-Verlag Berlin Heidelberg 2002.
PY - 2002
Y1 - 2002
N2 - We present a fully automated highly efficient technique which detects the multiple structural alignments of protein structures. Our method, MultiProt, finds the common geometrical cores between the input molecules. To date, only few methods were developed to tackle the structural multiple alignment problem. Most of them require that all the input molecules be aligned, while our method does not require that all the input molecules participate in the alignment. Actually, it efficiently detects high scoring partial multiple alignments for all possible number of molecules from the input. To demonstrate the power of the presented method we provide a number of experimental results performed by the implemented program. Along with the known multiple alignments of protein structures, we present new multiple structural alignment results of protein families from the All beta proteins class in the SCOP classification.
AB - We present a fully automated highly efficient technique which detects the multiple structural alignments of protein structures. Our method, MultiProt, finds the common geometrical cores between the input molecules. To date, only few methods were developed to tackle the structural multiple alignment problem. Most of them require that all the input molecules be aligned, while our method does not require that all the input molecules participate in the alignment. Actually, it efficiently detects high scoring partial multiple alignments for all possible number of molecules from the input. To demonstrate the power of the presented method we provide a number of experimental results performed by the implemented program. Along with the known multiple alignments of protein structures, we present new multiple structural alignment results of protein families from the All beta proteins class in the SCOP classification.
UR - http://www.scopus.com/inward/record.url?scp=84956971981&partnerID=8YFLogxK
U2 - 10.1007/3-540-45784-4_18
DO - 10.1007/3-540-45784-4_18
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AN - SCOPUS:84956971981
SN - 3540442111
SN - 9783540442110
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 235
EP - 250
BT - Algorithms in Bioinformatics - 2nd International Workshop,WABI 2002, Proceedings
A2 - Guigo, Roderic
A2 - Gusfield, Dan
PB - Springer Verlag
T2 - 2nd International Workshop on Algorithms in Bioinformatics, WABI 2002
Y2 - 17 September 2002 through 21 September 2002
ER -