Multipoint interval mapping of quantitative trait loci, using sib pairs

D. W. Fulker*, S. S. Cherny, L. R. Cardon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is a substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data.

Original languageEnglish
Pages (from-to)1224-1233
Number of pages10
JournalAmerican Journal of Human Genetics
Issue number5
StatePublished - May 1995
Externally publishedYes


FundersFunder number
Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentP01HD011681


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