TY - JOUR
T1 - Multiplication product of Model for End-stage Liver Disease and Donor Risk Index as predictive models of survival after liver transplantation
AU - Khalaileh, Abed
AU - Khoury, Tawfik
AU - Harkrosh, Subhi
AU - Nowotny, Yakob
AU - Massarwa, Mohamad
AU - Safadi, Rifaat
AU - Mor, Eytan
AU - Nakache, Richard
AU - Gazala, Samir Abu
AU - Merhav, Hadar
N1 - Publisher Copyright:
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Background Liver transplantation (LT) is the treatment of choice for most end-stage liver diseases. This treatment increases survival rates and improves quality of life. Because of the shortage of organ donors, as opposed to waiting patients, the need to optimize the matching of donors to recipients for maximum utility is crucial. Aim The aim of this study was to examine a predictive model based on the combination of donor and recipient risk factors using the liver Donor Risk Index (DRI) and recipient Model of End-stage Liver Disease (MELD) to predict patients’ survival following LT. Patients and methods The charts of 289 adult primary LT patients, who had undergone transplantation in Israel between 2010 and 2015, were studied retrospectively using prospectively gathered data. Results Two variables, DRI and MELD, were found to significantly affect post-transplant patient survival. DRI negatively affected survival in a continuous fashion, whereas MELD had a significantly negative effect only at MELD more than 30. Both female sex and the presence of hepatocellular carcinoma were associated with increased patient survival. Conclusion According to our findings, the model described here is a novel prediction tool for the success of orthotopic LT and can thus be considered in liver allocation.
AB - Background Liver transplantation (LT) is the treatment of choice for most end-stage liver diseases. This treatment increases survival rates and improves quality of life. Because of the shortage of organ donors, as opposed to waiting patients, the need to optimize the matching of donors to recipients for maximum utility is crucial. Aim The aim of this study was to examine a predictive model based on the combination of donor and recipient risk factors using the liver Donor Risk Index (DRI) and recipient Model of End-stage Liver Disease (MELD) to predict patients’ survival following LT. Patients and methods The charts of 289 adult primary LT patients, who had undergone transplantation in Israel between 2010 and 2015, were studied retrospectively using prospectively gathered data. Results Two variables, DRI and MELD, were found to significantly affect post-transplant patient survival. DRI negatively affected survival in a continuous fashion, whereas MELD had a significantly negative effect only at MELD more than 30. Both female sex and the presence of hepatocellular carcinoma were associated with increased patient survival. Conclusion According to our findings, the model described here is a novel prediction tool for the success of orthotopic LT and can thus be considered in liver allocation.
KW - Donor risk
KW - Liver transplantation
KW - Model of End-stage Liver Disease
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85071178263&partnerID=8YFLogxK
U2 - 10.1097/MEG.0000000000001396
DO - 10.1097/MEG.0000000000001396
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C2 - 30870222
AN - SCOPUS:85071178263
SN - 0954-691X
VL - 31
SP - 1116
EP - 1120
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
IS - 9
ER -